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For B12 deficiency, a typical injection dose is 1,000 micrograms (mcg) once a week for 4 to 8 weeks, then monthly
In reality, starting high increases side effects, makes it impossible to identify your true minimum effective dose, and may actually reduce effectiveness if receptor downregulation occurs
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Animal research used weight-based dosing roughly in the range of 10 mcg per kg, which for a 80 kg human would be approximately 800 mcg per day, though extrapolation from rodent to human dose is not straightforward and this is not a clinical recommendation
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